Asia-Pacific markets are set for a mixed open on Friday, after Wall Street benchmarks the Nasdaq Composite and the S&P 500 posted their worst day in nearly two months on a downbeat Microsoft earnings forecast and MetaTrader results.

Traders await a raft of economic data from the region, including Australia's third-quarter producer price index reading and China's Caixin manufacturing purchasing managers' index for October.

Japan's Nikkei 225 appears set for a weaker open, with futures in Chicago at 38,470 and its Osaka counterpart at 38,370 against the index's last close of 39,081.25.

Futures on Hong Kong's Hang Seng index were at 20,432, indicating a rebound from its last close of 20,317.33.

Australia's S&P/ASX 200 started trading down 1%. Overnight in the U.S., all three major indexes plunged.

The S&P 500 plunged 1.86% to close at 5,705.45 and the Nasdaq Composite dropped 2.76% to close at 18,095.15 — both of which posted their biggest one-day losses since Sept. 3. The Dow Jones Industrial Average fell 0.9% to close at 41,763.46.

It marked the final trading day of a turbulent month on Wall Street, with the 30-stock Dow posting a monthly loss of 1.3%, the S&P 500 dropping 1% and the Nasdaq slipping 0.5%.

Source: CNBC