The Nikkei 225 index fell 0.23% to close at 39,365, while the broader Topix index fell 0.37% to 2,728 on Tuesday, reversing earlier gains on caution ahead of the U.S. Federal Reserve's policy decision later this week.
The Fed is widely expected to cut interest rates by 25 basis points, but could signal fewer cuts next year amid concerns over a resurgence in inflation.
At home, speculation is growing that the Bank of Japan may delay a rate hike this week as BOJ officials wait for more time to assess the latest economic data.
In corporate news, Advantest shares plunged 9.1% after it launched its latest testing solution for advanced applications. Meanwhile, SoftBank Group rose 4.3% after CEO Masayoshi Son announced plans to invest $100 billion in the U.S.
Sorce: Trading Economics
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